There is little information about the prevalence of sexually transmitted infections (STIs) in pregnant women in Mozambique. In Tete, a province in the country's northwest, recent data are not available. However, the province's Directorate of Health reported an antenatal clinic (ANC) attendance rate of nearly 100%. This study set out to assess the prevalence of Chlamydia trachomatis (CT), Neisseria gonorrhoeae (G) and syphilis in pregnant women attending urban health centres.